Ferrostatin-1

• Background:

  Ferrostatin-1 inhibits ferroptosis (EC50=60 nM), an iron-dependent form of nonapoptotic cell death. It is especially potent of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices (1). It also blocks the cytotoxic effects of sorafenib in hepatocellular carcinoma cells (2), and inhibits oxidative lipid damage and cell death in diverse disease models (3). It has also been shown to mitigate rotenone-induced a-synuclein aggregation (4).

• Description:

  Ferroptosis Inhibitor

• Product Name Alternative:

  Ethyl 3-amino-4- (cyclohexylamino) benzoate

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis | Cell Signaling | Neuroscience | Neurodegeneration | Parkinson's Disease | Synuclein

• Purity:

  >98% (TLC) ; NMR (Conforms)

• Weight:

  0.005

• Format:

  Tan powder

• Solubility:

  Soluble in DMSO (100 mg/ml) or ethanol (100 mg/ml)

• Molecular Formula:

  C15H22N2O2

• Molecular Weight:

  262.4

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Dixon S.J., et al. (2012) Cell. 149: 1060. 2. Louandre C., et al. (2013) Int. J. Cancer. 133: 1732. 3. Skouta R., et al. (2014) J. Am. Chem. Soc. 136: 4551. 4. P Kabiraj et al; Protein J., 2015 34; 349

• CAS Number:

  347174-05-4