PAC-1

CAT: 0400-SIH-569-5MGSize: 5 mgDry Ice: NoHazardous: No
CAT#:0400-SIH-569-5MGSize:5 mg
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Background
PAC-1 is a procaspase-activating compound, directly activating procaspase-3, producing caspase-3 (1); it is less potent at activating procaspase-7. It induces apoptosis in a variety of cancer cell lines by activation involving sequestering inhibitory zinc ions thus allowing procaspase-3 to autoactivate (2).
Description
Procaspase-3 activator
CAS Number
315183-21-2
Product Name Alternative
4- (Phenylmethyl) -1-piperazineacetic acid [[2-hydroxy-3- (2-propenyl) phenyl]-methylene]hydrazide
UNSPSC
41116105
Type
Activator
Source
Synthetic
Field of Research
Cancer | Cell Cycle | Apoptosis | Caspases | Cell Signaling | Neuroscience
Purity
>98% (HPLC) ; NMR (Conforms)
Weight
0.005
Format
Off-White powder
Solubility
May be dissolved in DMSO (35 mg/ml); or ethanol (15 mg/ml)
Molecular Formula
C23H28N4O2
Molecular Weight
392.5
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Putt K.S., et al., (2006) Nat. Chem. Biol. 2:543. 2. Peterson Q.P., et al., (2009) J. Mol. Biol. 388:144.

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