PAC-1

• Background:

  PAC-1 is a procaspase-activating compound, directly activating procaspase-3, producing caspase-3 (1); it is less potent at activating procaspase-7. It induces apoptosis in a variety of cancer cell lines by activation involving sequestering inhibitory zinc ions thus allowing procaspase-3 to autoactivate (2).

• Description:

  Procaspase-3 activator

• Product Name Alternative:

  4- (Phenylmethyl) -1-piperazineacetic acid [[2-hydroxy-3- (2-propenyl) phenyl]-methylene]hydrazide

• UNSPSC:

  41116105

• Type:

  Activator

• Source:

  Synthetic

• Field of Research:

  Cancer | Cell Cycle | Apoptosis | Caspases | Cell Signaling | Neuroscience

• Purity:

  >98% (HPLC) ; NMR (Conforms)

• Weight:

  0.005

• Format:

  Off-White powder

• Solubility:

  May be dissolved in DMSO (35 mg/ml); or ethanol (15 mg/ml)

• Molecular Formula:

  C23H28N4O2

• Molecular Weight:

  392.5

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Putt K.S., et al., (2006) Nat. Chem. Biol. 2:543. 2. Peterson Q.P., et al., (2009) J. Mol. Biol. 388:144.

• CAS Number:

  315183-21-2