Spautin-1

• Background :

  Spautin-1 inhibits the deubiquitination activity of USP10 and USP13, two ubiquitin-specific peptidases. This results in the degradation of class III PI3 kinase complexes. Because this group of kinases regulates autophagy, Spautin-1 in turn inhibits autophagy.

• Description :

  Autophagy inhibitor

• Product Name Alternative :

  6-Fluoro-N-[ (4-fluorophenyl) methyl]-4-quinazolinamine

• UNSPSC :

  41116105

• Type :

  Inhibitor

• Source :

  Synthetic

• Field of Research :

  Cancer | Autophagy

• Purity :

  ≥98% (TLC) ; NMR (Conforms)

• Weight :

  0.025

• Format :

  White to beige powder.

• Solubility :

  May be dissolved in DMSO (50mg/mL); or ethanol (15mg/mL, warm)

• Molecular Formula :

  C15H11F2N3

• Molecular Weight :

  271.26

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Liu J., et al. (2011) Cell. 147(1): 223-34.

• CAS Number :

  1262888-28-7