JC-1

• Background:

  JC-1 is a fluorescent dye that is able to pass across the mitochondrial membrane. It is used to measure mitochondrial membrane potential. At low membrane potentials, it remains a monomer and emits green-fluorescent light (λex=485 nm, λem=520 nm). At higher membrane potentials, it forms "J-aggregates", which emit red-fluorescent light (λex=520-570 nm, λem=570-610 nm). The ratio of red/green fluorescence is based only on the membrane potential, and not on mitochondrial size, shape or density.

• Description:

  Mitochondrial membrane-potential dependent fluorescent dye

• Product Name Alternative:

  5,5,6,6-Tetrachloro-1,1,3,3-tetraethylbenzimidazolylcarbocyanine iodide, , 5,6-dichloro-2-[ (E) -3- (5,6-dichloro-1,3-diethylbenzimidazol-3-ium-2-yl) prop-2-enylidene]-1,3-diethylbenzimidazole; iodide, Jc-1; 3520-43-2; JC-1 jodide; JC1 dye; CBIC2 (3) ; 5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine iodide

• UNSPSC:

  41116105

• Type:

  Membrane Potential Probe

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis | Mitochondrial | Cell Cycle | Tags and Cell Markers | Fluorescent Proteins

• Purity:

  >98% (HPLC) ; NMR (Conforms)

• Weight:

  0.005

• Format:

  Red powder

• Solubility:

  May be dissolved in DMSO (20 mg/ml)

• Molecular Formula:

  C25H27Cl4IN4

• Molecular Weight:

  652.2

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• CAS Number:

  3520-43-2