PROTAC SMARCA2/4-degrader-10

• UNSPSC Description:

  PROTAC SMARCA2/4-degrader-10 (compound I-399) is a potent SMARCA2 degrader with an DC50 value of [1].

• Target Antigen:

  Epigenetic Reader Domain; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-smarca2-4-degrader-10.html

• Smiles:

  NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)C3=CN(C4CCN(CC4)CC[C@@H]5CC[C@H](CC5)C(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)=O)=O)N=C3

• Molecular Weight:

  903.15

• References & Citations:

  [1]Nan Ji, et al. Smarca degraders and uses thereof. US20230072658A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2568277-33-6