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PROTAC BRD4 Degrader-10

CAT: 0931-T40073-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T40073-01Size:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2417370-49-9
Target
PROTACs, Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic, PROTAC
Bioactivity
PROTAC BRD4 Degrader-10, also known as compound 8b, is a dual ligand-based PROTAC that combines ligands for von Hippel-Lindau and BRD4. To degrade the BRD4 protein in PC3 prostate cancer cells, PROTAC BRD4 Degrader-10 can be conjugated with STEAP1 and CLL1 antibodies, with respective DC 50 values of 1.3 nM and 18 nM.
Smiles
CC(OC(=O)O[C@@H]1C[C@H](N(C1)C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)c1cc2N(Cc3c[nH]c4c3c(cn(C)c4=O)-c2cc1CS(C)(=O)=O)c1ncc(F)cc1F)C(C)(C)C)C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)SS(C)(=O)=O
Molecular Formula
C59H71F2N9O15S4
Molecular Weight
1312.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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