VEGFR-2/STAT-3-IN-1

• UNSPSC Description:

  VEGFR-2/STAT-3-IN-1 (Compound 9f) is a dual inhibitor for VEGFR-2 (IC50=26.3 nM) and STAT-3 (IC50=5.63 nM). VEGFR-2/STAT-3-IN-1 inhibits the proliferation of cancer cells PANC1 and PC3 with IC50 of 0.14 and 0.10 µM. VEGFR-2/STAT-3-IN-1 induces apoptosis in PC3[1].

• Target Antigen:

  STAT; VEGFR

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/vegfr-2-stat-3-in-1.html

• Smiles:

  O=C(N1C(C2=CC=CC=C2)=O)/C(C3=C1C=CC=C3)=N\NC(C4=C(C)N(C5=CC=C(OC)C=C5)N=N4)=O

• Molecular Weight:

  480.47

• References & Citations:

  [1]Elsebaie HA, et al., Unveiling the potential of isatin-grafted phenyl-1,2,3-triazole derivatives as dual VEGFR-2/STAT-3 inhibitors: Design, synthesis and biological assessments. Bioorg Chem. 2024 Jul 10;151:107626.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported