A 1120

• Description :

  A 1120 is a high-affinity nonretinoid retinol-binding protein 4 (RBP4) antagonist with a Ki value of 8.3 nM. A 1120 disrupts the interaction between RBP4 and its binding partner transthyretin[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H317, H319, H400

• Target :

  Transthyretin (TTR)

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/a-1120.html

• Purity :

  99.73

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  FC(F)(C1=C(C2CCN(C(NC3=C(C=CC=C3)C(O)=O)=O)CC2)C=CC=C1)F

• Molecular Formula :

  C20H19F3N2O3

• Molecular Weight :

  392.37

• Precautions :

  H302, H317, H319, H400

• References & Citations :

  [1]Motani A, et al. Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo. J Biol Chem. 2009 Mar 20;284 (12) :7673-80.|[2]Dobri N, et al. A1120, a nonretinoid RBP4 antagonist, inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis. Invest Ophthalmol Vis Sci. 2013 Jan 7;54 (1) :85-95.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1152782-19-8]