MEN 11270

CAT: 0804-HY-103289-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-103289-01Size:1 mg
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Description
MEN 11270, a cyclic decapeptide, is a B2 kinin receptor antagonist. MEN 11270 bound with high-affinity to the B2 kinin receptor constitutively expressed by WI38 human fibroblasts, inhibiting 3H-bradykinin (BK) with a pKi value of 10.3[1].
CAS Number
[235082-52-7]
UNSPSC
12352209
Target
Bradykinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/men-11270.html
Purity
99.15
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@]1([H])N(C([C@H]2NC([C@@H](NC(CNC([C@H](C[C@H]3O)N(C3)C([C@H](CCC4)N4C([C@H](CCCNC(N)=N)NC([C@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)CC5=CC=CS5)=O)=O)CC6=CC=CC=C6C1)N7[C@](CCCC8)([H])[C@]8([H])C[C@@]7([H])C(N[C@H](C(NCC2)=O)CCCNC(N)=N)=O
Molecular Formula
C60H90N20O11S
Molecular Weight
1299.55
References & Citations
[1]Meini S, et, al. MEN 11270, A novel selective constrained peptide antagonist with high affinity at the human B2 kinin receptor. J Pharmacol Exp Ther. 1999 Jun;289 (3) :1250-6.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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