CVS-1123

• Description :

  CVS-1123 is an orally active direct thrombin inhibitor. CVS-1123 inhibits in vitro platelet aggregation of γ-thrombin and prolongs activated partial thromboplastin time. CVS-1123 alters the thrombotic response to deep vessel wall damage in arterial and venous circulation. CVS-1123 can be used in antithrombotic studies[1][2]

• UNSPSC :

  12352005

• Target :

  Thrombin

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Cardiovascular Disease

• Smiles :

  O=C([C@H](CC(OC)=O)NC(C(CCC)CCC)=O)N1[C@H](C(N[C@H](C=O)CCCNC(N)=N)=O)CCC1

• Molecular Formula :

  C24H42N6O6

• Molecular Weight :

  510.63

• References & Citations :

  [1]Rebello SS, et al. CVS-1123, a direct thrombin inhibitor, prevents occlusive arterial and venous thrombosis in a canine model of vascular injury. J Cardiovasc Pharmacol. 1997 Feb;29 (2) :240-9.|[2]Cousins GR, et al. Orally effective CVS-1123 prevents coronary artery thrombosis in the conscious dog. Circulation. 1996 Oct 1;94 (7) :1705-12.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [151275-19-3]