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DFP-11207

CAT: 0804-HY-114249Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-114249Size:1 Each
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Description
DFP-11207 is an orally active fluoropyrimidine cytotoxic agent. DFP-11207 combines a 5-FU pro-drug with a reversible DPD inhibitor and a potent inhibitor of OPRT, resulting in enhanced pharmacological activity of 5-FU with decreased gastrointestinal and myelosuppressive toxicities. DFP-11207 can be used for the research of cancer.
CAS Number
1296177-16-6
UNSPSC
12352005
Target
Dihydropyrimidine Dehydrogenase (DPD) ; Nucleoside Antimetabolite/Analog
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(C1=CC(OC(CC)=O)=NC(OC(CC)=O)=C1)OC2=CC(OC(C3=CC=CC(C(N(C(N(COCC)C=C4F)=O)C4=O)=O)=C3)=O)=NC=C2Cl
Molecular Formula
C32H26ClFN4O12
Molecular Weight
713.02
References & Citations
[1]Ajani JA, et al. Phase I study of DFP-11207, a novel oral fluoropyrimidine with reasonable AUC and low Cmax and improved tolerability, in patients with solid tumors. Invest New Drugs. 2020 Dec;38 (6) :1763-1773.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

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