TX-1123

• Description :

  TX-1123 is a potent protein tyrosine kinase (PTK) inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC. TX-1123 is a cyclo-oxygenase (COX) inhibitor with IC50 values of 1.16 μM and 15.7 μM for COX2 and COX1, respectively. TX-1123 has low mitochondrial toxicity. TX-1123 can be used in research of cancer[1][2].

• UNSPSC :

  12352005

• Target :

  CaMK; COX; EGFR; PKA; PKC; Src

• Type :

  Reference compound

• Related Pathways :

  Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Neuronal Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; TGF-beta/Smad

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/tx-1123.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1/C(C(C=C1)=O)=C\C2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2

• Molecular Formula :

  C20H24O3

• Molecular Weight :

  312.40

• References & Citations :

  [1]Hori H, et, al. TX-1123: an antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity. Bioorg Med Chem. 2002 Oct;10 (10) :3257-65.|[2]Ohkura K, et, al. Interactive Analysis of TX-1123 with Cyclo-oxygenase: Design of COX2 Selective TX Analogs. Anticancer Res. 2017 Jul;37 (7) :3849-3854.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  COX-1; COX-2

• CAS Number :

  [157397-06-3]