PZ-1129

• Description:

  PZ-1129 is a selective 5-HT7 receptor ligand with a Ki of 7 nM. PZ-1129 shows Ki values of 159 and 24 nM for 5-HT1A receptor and D2 receptor. PZ-1129 can inhibit the constitutive cAMP production mediated by the Gs signaling pathway (EC50 = 13.7 nM) . PZ-1129 can be used for the research of emotional disorders, such as depression and bipolar disorder[1].

• UNSPSC:

  12352005

• Target:

  5-HT Receptor; Dopamine Receptor

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Smiles:

  O=S (NC1CCN (CC1) CCOC2=C (C3=CC=CC=C3) C=CC=C2) (C4=CC=C (C=C4) F) =O

• Molecular Formula:

  C25H27FN2O3S

• Molecular Weight:

  454.56

• References & Citations:

  [1]Canale V, et al. Fine-tuning 5-HT7 receptor selectivity, inverse agonism, and metabolic stability of new (aryloxy) ethyl-piperidines toward antidepressant and pro-cognitive properties. Eur J Med Chem. 2026 Jan 15;302 (Pt 3) :118369.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  5-HT1 Receptor;5-HT2 Receptor;5-HT6 Receptor;5-HT7 Receptor; D2 Receptor

• CAS Number:

  1919029-61-0