PROTAC SMARCA2 degrader-14

PROTAC SMARCA2 degrader-14

• CAS Number: 2568276-73-1
• UNSPSC Description: SMARCA2 degrader-3 (compound I-323) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 90 after 24 h of treatment[1].
• Target Antigen: PROTACs
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-smarca2-degrader-14.html
• Smiles: O=C1NC(C(CC1)N2C(C3=CC=C(NC4CCC(CC4)N5CCC(CC5)N6N=CC(C7=C(N)N=NC(C8=C(O)C=CC=C8)=C7)=C6)C=C3C2=O)=O)=O
• Molecular Weight: 689.76
• References & Citations: [1]Preparation of heterocyclic compounds as SMARCA degraders and uses thereof. World Intellectual Property Organization, WO2020251971 A1 2020-12-17.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported