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PROTAC SMARCA2 degrader-5

CAT: 0804-HY-159449Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-159449Size:1 Each
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Description
PROTAC SMARCA2 degrader-5 (Compound I-425) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2 degrader-5 degrades SMARCA2 in MV411 and in A549 with DC50 SMARCA4 with DC50 of 100-500 nM[1]. (Pink: Ligand for target protein ; Black: Linker (HY-159538) ; Blue: Ligand for E3 ligase (S, R, S) -AHPC (HY-125845) )
CAS Number
2568277-68-7
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-smarca2-degrader-5.html
Smiles
O=C([C@H]1N(C([C@@H](NC(C2(CC3)CCC3(CN4CCC(C5=CN=C(N6C7CN(C8=CC(C9=CC=CC=C9O)=NN=C8N)CC6CC7)N=C5)CC4)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC%10=CC=C(C%11=C(C)N=CS%11)C=C%10
Molecular Formula
C57H72N12O5S
Molecular Weight
1037.32
References & Citations
[1]Ji N, et al., Smarca degraders and uses thereof. US20230072658A1. |[2]Ji N, et al., Smarca degraders and uses thereof. US20230072658A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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