PROTAC SMARCA2 degrader-5

• UNSPSC Description:

  PROTAC SMARCA2 degrader-5 (Compound I-425) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2 degrader-5 degrades SMARCA2 in MV411 and in A549 with DC50 SMARCA4 with DC50 of 100-500 nM[1]. (Pink: Ligand for target protein (HY-159531); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

• Target Antigen:

  Epigenetic Reader Domain; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-smarca2-degrader-5.html

• Smiles:

  O=C([C@H]1N(C([C@@H](NC(C2(CC3)CCC3(CN4CCC(C5=CN=C(N6C7CN(C8=CC(C9=CC=CC=C9O)=NN=C8N)CC6CC7)N=C5)CC4)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC%10=CC=C(C%11=C(C)N=CS%11)C=C%10

• Molecular Weight:

  1037.32

• References & Citations:

  [1]Ji N, et al., Smarca degraders and uses thereof. US20230072658A1. |[2]Ji N, et al., Smarca degraders and uses thereof. US20230072658A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2568277-68-7