Products for Research Use Only
RegisterLogin

SB 203580 sulfone

CAT: 0804-HY-112349-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-112349-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
SB 203580 sulfone is an analog of p38 MAP kinase inhibitor SB 203580. SB 203580 sulfone inhibits the IL-1 production (IC50 of 0.2 μM in monocytes) and binds competitively with CSAID binding proteins (CSBP), inhibits it mediated stress response signaling with an IC50 of 0.03 μM. SB 203580 sulfone inhibits 5-LO with an IC50 value of 24 µM. SB 203580 sulfone can be used in the research of inflammatory diseases[1][2].
CAS Number
152121-46-5
UNSPSC
12352005
Target
Drug Derivative; Interleukin Related; Lipoxygenase
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sb-203580-sulfone.html
Purity
99.25
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 50 mg/mL (ultrasonic; warming)
Smiles
O=S(C1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1)(C)=O
Molecular Formula
C21H16FN3O2S
Molecular Weight
393.43
References & Citations
[1]Gallagher TF, et al., Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase. Bioorg Med Chem. 1997 Jan;5 (1) :49-64.|[2]Timothy F, et al. 2,4,5- triarylimidazole inhibitors of IL-1 biosynthesis. Bioorganic & Medicinal Chemistry Letters, 1995, 1171-1176.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1

Related Products

CatalogName
HY-135439SB-203186
HY-101222-01SB-203186 (hydrochloride)
HY-10666SB-436811
HY-144898-01SB-216
HY-13409-01SB 242084
HY-12043-01SB 525334
HY-112367SB 202474
HY-117574SB 207710
HY-117854SB 201146
HY-125082SB 204144

Alternative Products

CatalogName
T84519-01SB 203580 sulfone
MBS3602124-01SB 203580
GTR19177741-01SB-203580

Popular Products