SB 202474

• Description :

  SB 202474, a negative analog of SB203580. SB 202474, which has no ability to inhibit p38 MAPK activity and is widely used as a negative control compound in p38 MAPK studies, also suppressed melanin synthesis induction[1].

• CAS Number :

  [172747-50-1]

• UNSPSC :

  12352005

• Target :

  P38 MAPK

• Type :

  Reference compound

• Related Pathways :

  MAPK/ERK Pathway

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/sb-202474.html

• Solubility :

  10 mM in DMSO

• Smiles :

  COC1=CC=C(C2=NC(CC)=C(C3=CC=NC=C3)N2)C=C1

• Molecular Formula :

  C17H17N3O

• Molecular Weight :

  279.34

• References & Citations :

  [1]Bellei B, et al. p38 regulates pigmentation via proteasomal degradation of tyrosinase. J Biol Chem. 2010;285 (10) :7288-7299.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported