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SB 201146

CAT: 0804-HY-117854Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117854Size:1 Each
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Description
SB 201146 is an LTB4 receptor antagonist with a potency range of 10 pM to 1 μM that plays a critical role in asthma-associated airway inflammation. Studies have focused on its effects on eosinophil survival, a hallmark of asthma pathology. Studies have shown that eosinophil-derived cysteinyl leukotrienes, including LTC4 and LTD4, as well as factors such as GM-CSF and fibronectin promote eosinophil survival. SB 201146 effectively reversed mast cell- and lymphocyte-induced eosinophil survival, highlighting its potential therapeutic role in disrupting the autocrine cysteinyl leukotriene pathway that maintains eosinophil viability. This antagonist also highlights the importance of LTB4 as a paracrine mediator that influences eosinophil survival in inflammatory settings such as asthma[1].
CAS Number
141311-11-7
UNSPSC
12352005
Target
Leukotriene Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sb-201146.html
Smiles
O=C(O[Li])/C=C/C1=NC(CS(C2=CC=CC(N)=C2)=O)=CC=C1OCCCCCCCCC3=CC=C(OC)C=C3
Molecular Formula
C30H35LiN2O5S
Molecular Weight
542.62
References & Citations
[1]Leukotriene receptor antagonists and synthesis inhibitors reverse survival in eosinophils of asthmatic individuals
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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