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SB 207710

CAT: 0804-HY-117574Size: 1 EachDry Ice: NoHazardous: No
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Description
SB 207710 is a highly selective antagonist of the 5-HT4 receptor that has been shown to effectively block the positive inotropic effect induced by serotonin in human right atrial appendage preparations[1].
CAS Number
148703-08-6
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sb-207710.html
Smiles
O=C(OCC1CCN(CC1)CCCC)C2=C3OCCOC3=C(C(I)=C2)N
Molecular Formula
C19H27IN2O4
Molecular Weight
474.33
References & Citations
[1]Kaumann A J, et al. Blockade of human atrial 5-HT 4 receptors by SB 207710, a selective and high affinity 5-HT 4 receptor antagonist[J]. Naunyn-Schmiedeberg's archives of pharmacology, 1994, 349: 546-548.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

SB-207710

structure given in first source

CAS Number148703-08-6
PubChem CID5311423
IUPAC Name(1-butylpiperidin-4-yl)methyl 5-amino-6-iodo-2,3-dihydro-1,4-benzodioxine-8-carboxylate
Molecular FormulaC19H27IN2O4
Molecular Weight474.3
XLogP3.5
Topological Polar Surface Area74
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Heavy Atom Count26
Formal Charge0
Complexity459
SMILES
CCCCN1CCC(CC1)COC(=O)C2=CC(=C(C3=C2OCCO3)N)I
InChI
InChI=1S/C19H27IN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3
InChIKey
FCKKCDRMGKXQDK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of SB-207710
CAS: 148703-08-6
CID: 5311423
Formula: C19H27IN2O4
MW: 474.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight474.3
XLogP33.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass474.10155
Monoisotopic Mass474.10155
Topological Polar Surface Area74 Ų
Heavy Atom Count26
Formal Charge0
Complexity459
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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