SB 525334

CAT: 0804-HY-12043-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12043-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
SB 525334 is a potent and selective transforming growth factor β1 receptor (ALK5) inhibitor with an IC50 of 14.3 nM.
CAS Number
[356559-20-1]
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335, H413
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SB-525334.html
Purity
99.97
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(C)(C1=NC(C2=CC=CC(C)=N2)=C(C3=CC=C4N=CC=NC4=C3)N1)C
Molecular Formula
C21H21N5
Molecular Weight
343.42
Precautions
H301, H315, H319, H335, H413
References & Citations
[1]Grygielko ET, et al. Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis. J Pharmacol Exp Ther, 2005, 313 (3), 943-951.|[2]Thomas M, et al. ALK5 mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrotaline. Am J Pathol, 2009, 174 (2), 380-389.|[3]Laping NJ, et al. Tumor-specific efficacy of transforming growth factor-beta RI inhibition in Eker rats. Clin Cancer Res, 2007, 13 (10), 3087-3899.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-18596-01SB-215505
HY-149300SB-1436
HY-171854SB-583355
HY-122286SB 414240
HY-106337SB 247083
HY-108333-01SB-633825
HY-10656-01SB-657510
HY-103112B-01SB 243213
HY-10806-01SB-649868
HY-120835SB-202742

Alternative Products

CatalogName
2880-25SB-525334
M14224-01SB 525334
2881-5EZSolution™ SB-525334
A10827-10SB 525334 10mg
A10827-200SB 525334 200mg
A10827-100SB 525334 100mg
A10827-25SB 525334 25mg
A10827-50SB 525334 50mg
A10827-5SB 525334 5mg
TBI2983-25MGSB-525334, ALK5

Popular Products