SB-3CT

• Description :

  SB-3CT is a potent and competitive matrix metalloproteinase MMP-2 and MMP-9 inhibitor with Ki values of 13.9 and 600 nM, respectively. SB-3CT has high selectivity for gelatinases. SB-3CT shows blood-brain barrier permeability and has neuroprotective effects and anticancer activity[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H319

• Target :

  MMP

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/SB-3CT.html

• Purity :

  99.84

• Solubility :

  DMSO : ≥ 50 mg/mL

• Smiles :

  O=S(CC1SC1)(C2=CC=C(OC3=CC=CC=C3)C=C2)=O

• Molecular Formula :

  C15H14O3S2

• Molecular Weight :

  306.40

• Precautions :

  H319

• References & Citations :

  [1]Lee M, et al. Water-Soluble MMP-9 Inhibitor Reduces Lesion Volume after Severe Traumatic Brain Injury. ACS Chem Neurosci. 2015 Oct 21;6 (10) :1658-64.|[2]Stephen Brown, et al. Potent and Selective Mechanism-Based Inhibition of GelatinasesJ. Am. Chem. Soc.2000122286799-6800|[3]Bonfil RD, et al. Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism-based selective gelatinase inhibitor. Int J Cancer. 2006, 118 (11), 2721-2726.|[4]Cui J, et al. Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia. Mol Neurodegener. 2012, 15, 7-21.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MMP-2; MMP-9

• CAS Number :

  [292605-14-2]