Donepezil (Hydrochloride)

• UNSPSC Description:

  Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC50 of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE[1]. Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity[2].

• Target Antigen:

  Cholinesterase (ChE)

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Donepezil-Hydrochloride.html

• Purity:

  99.92

• Solubility:

  DMSO : 6.2 mg/mL (warming)|H2O : 25 mg/mL (ultrasonic)

• Smiles:

  O=C1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=C1C=C(OC)C(OC)=C4.[H]Cl

• Molecular Weight:

  415.95

• References & Citations:

  [1]H Ogura, et al. Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol. 2000 Oct;22(8):609-13.|[2]Min-Young Noh,et al. Neuroprotective effects of donepezil through inhibition of GSK-3 activity in amyloid-beta-induced neuronal cell death. J Neurochem. 2009 Mar;108(5):1116-25.|[3]Chang Yell Shin, et al. The Effects of Donepezil, an Acetylcholinesterase Inhibitor, on Impaired Learning and Memory in Rodents. Biomol Ther (Seoul). 2018 May 1;26(3):274-281.Clin Transl Med. 2021 May 28.|J Integr Neurosci. 2023 May 16, 22(3), 76.|Patent. US20210378961A1.|Research Square Preprint. 2024 Apr 23.|Comput Struct Biotec. 2023 Feb 24.|Eur J Med Chem. 2023 Dec 21, 116071.|Foods. 2022, 11(14), 2095.|Journal of Pharmaceutical Investigation. 2021 Mar 31.|Phytomedicine. 2024 Jun 4:131:155802.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  Launched

• CAS Number:

  120011-70-3