Donepezil-d7

CAT: 0804-HY-W727525Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-W727525Size:1 Each
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Description
Donepezil-d7 (E2020-d7 (free base) ) is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].
CAS Number
[1215071-00-3]
Product Name Alternative
E2020-d7 (free base)
UNSPSC
12352005
Target
Cholinesterase (ChE) ; Isotope-Labeled Compounds
Related Pathways
Neuronal Signaling; Others
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease; Cancer
Smiles
O=C1C(CC2CCN(C(C3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])([2H])[2H])CC2)CC4=C1C=C(OC)C(OC)=C4
Molecular Formula
C24H22D7NO3
Molecular Weight
386.54
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22 (8) : p. 609-13.|[3]Snape, M.F., et al., A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology, 1999. 38 (1) : p. 181-93.|[4]Huang, Z.H., et al., Donepezil protects endothelial cells against hydrogen peroxide-induced cell injury. CNS Neurosci Ther, 2012. 18 (2) : p. 185-7.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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