Donepezil

• UNSPSC Description:

  Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].

• Target Antigen:

  Cholinesterase (ChE)

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/donepezil.html

• Solubility:

  DMSO : 33.33 mg/mL (ultrasonic)

• Smiles:

  O=C(C(C=C(OC)C(OC)=C1)=C1C2)C2CC(CC3)CCN3CC4=CC=CC=C4

• Molecular Weight:

  379.49

• References & Citations:

  [1]Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22(8): p. 609-13.|[2]Snape, M.F., et al., A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology, 1999. 38(1): p. 181-93.|[3]Huang, Z.H., et al., Donepezil protects endothelial cells against hydrogen peroxide-induced cell injury. CNS Neurosci Ther, 2012. 18(2): p. 185-7.Comput Struct Biotec. 2023 Feb 24.|Eur J Med Chem. 2023 Dec 21, 116071.|Foods. 2022, 11(14), 2095.|Journal of Pharmaceutical Investigation. 2021 Mar 31.|Phytomedicine. 2024 Jun 4:131:155802.|Clin Transl Med. 2021 May 28.|J Integr Neurosci. 2023 May 16, 22(3), 76.|Patent. US20210378961A1.|Research Square Preprint. 2024 Apr 23.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  Launched

• CAS Number:

  120014-06-4