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Donepezil (Standard)

CAT: 0804-HY-14566R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14566R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Donepezil (Standard) is the analytical standard of Donepezil. This product is intended for research and analytical applications. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].
CAS Number
120014-06-4
Product Name Alternative
E2020 (free base) (Standard)
UNSPSC
12352005
Hazard Statement
H300-H315-H319-H335
Target
Cholinesterase (ChE) ; Reference Standards
Type
Reference Standards
Related Pathways
Neuronal Signaling; Others
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/donepezil-standard.html
Smiles
O=C(C(C=C(OC)C(OC)=C1)=C1C2)C2CC(CC3)CCN3CC4=CC=CC=C4
Molecular Formula
C24H29NO3
Molecular Weight
379.49
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22 (8) : p. 609-13.|[2]Snape, M.F., et al., A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology, 1999. 38 (1) : p. 181-93.|[3]Huang, Z.H., et al., Donepezil protects endothelial cells against hydrogen peroxide-induced cell injury. CNS Neurosci Ther, 2012. 18 (2) : p. 185-7.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
Launched

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