Donepezil-d7 (hydrochloride)

Donepezil-d7 (hydrochloride)

• CAS Number: 1261394-20-0
• UNSPSC Description: Donepezil-d7 (hydrochloride) is the deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].
• Target Antigen: Cholinesterase (ChE); Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Neuronal Signaling;Others
• Field of Research: Neurological Disease
• Purity: 99.0
• Solubility: 10 mM in DMSO
• Smiles: O=C1C2=CC(OC)=C(OC)C=C2CC1CC3CCN(CC3)C([2H])([2H])C4=C([2H])C([2H])=C([2H])C([2H])=C4[2H].Cl
• Molecular Weight: 423.00
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22(8): p. 609-13.;Snape, M.F., et al., A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology, 1999. 38(1): p. 181-93.;Huang, Z.H., et al., Donepezil protects endothelial cells against hydrogen peroxide-induced cell injury. CNS Neurosci Ther, 2012. 18(2): p. 185-7.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported