Donepezil-d5

CAT: 0804-HY-14566S1Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-14566S1Size:1 mg
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Description
Donepezil-d5 is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].
CAS Number
[1128086-25-8]
Product Name Alternative
E2020-d5 (free base)
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Isotope-Labeled Compounds
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.30
Solubility
10 mM in DMSO|DMSO : 33.33mg/mL (ultrasonic) |H2O : 2mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C1C2=CC(OC)=C(OC)C=C2CC1CC3CCN(CC3)CC4=C([2H])C([2H])=C([2H])C([2H])=C4[2H]
Molecular Formula
C24H24D5NO3
Molecular Weight
384.52
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Huang, Z.H., et al., Donepezil protects endothelial cells against hydrogen peroxide-induced cell injury. CNS Neurosci Ther, 2012. 18 (2) : p. 185-7.|[3]Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22 (8) : p. 609-13.|[4]Snape, M.F., et al., A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology, 1999. 38 (1) : p. 181-93.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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