Donepezil-d5

• Description:

  Donepezil-d5 is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].

• Product Name Alternative:

  E2020-d5 (free base)

• UNSPSC:

  12352005

• Target:

  Cholinesterase (ChE)

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Purity:

  99.30

• Solubility:

  10 mM in DMSO|DMSO : 33.33mg/mL (ultrasonic) |H2O : 2mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles:

  O=C1C2=CC(OC)=C(OC)C=C2CC1CC3CCN(CC3)CC4=C([2H])C([2H])=C([2H])C([2H])=C4[2H]

• Molecular Formula:

  C24H24D5NO3

• Molecular Weight:

  384.52

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Huang, Z.H., et al., Donepezil protects endothelial cells against hydrogen peroxide-induced cell injury. CNS Neurosci Ther, 2012. 18 (2) : p. 185-7.|[3]Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22 (8) : p. 609-13.|[4]Snape, M.F., et al., A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology, 1999. 38 (1) : p. 181-93.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  1128086-25-8