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ClpP modulator-1

CAT: 0804-HY-175597Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175597Size:1 Each
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Description
ClpP modulator-1 (Compound BC8a), a peptidomimetic, is an allosteric ClpP modulator. ClpP modulator-1 is a ClpP activator at low concentration with EC50s of 0.35 and 0.58 μM for for Neisseria meningitides ClpP (NmClpP) and Escherichia coli ClpP (EcClpP), resepectively. ClpP modulator-1 also inhibits peptidase activity at high concentration by competitively inhibiting substrate protein (LY-AMC) binding to ClpP C sites. ClpP modulator-1 has antibacterial activity. ClpP modulator-1 can be used for bacterial infections research[1].
CAS Number
[2363753-48-2]
UNSPSC
12352100
Target
ClpP
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Infection
Smiles
COC1=CC(Cl)=C(C=C1)C(N[C@H](C(N[C@H](B(O)O)CC(C)C)=O)CC(C)C)=O
Molecular Formula
C19H30BClN2O5
Molecular Weight
412.72
References & Citations
[1] Barghash MM, et al. Small molecule dysregulation of ClpP activity via bidirectional allosteric pathways. Structure. 2025 Aug 5:S0969-2126 (25) 00261-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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