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SB-222200

CAT: 0804-HY-15722-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15722-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SB-222200 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant NK-3 receptor antagonist. SB-222200 is developed for central nervous system (CNS) disorders[1].
CAS Number
174635-69-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/SB-222200.html
Purity
99.85
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C1=C(C)C(C2=CC=CC=C2)=NC3=CC=CC=C13)N[C@H](C4=CC=CC=C4)CC
Molecular Formula
C26H24N2O
Molecular Weight
380.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Sarau HM, et al. Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist. J Pharmacol Exp Ther. 2000 Oct;295 (1) :373-81.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NK3R

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Alternative Products

CatalogName
526724SB-222200
MBS130146-01SB 222200
A15230-25SB-222200 25mg
A15230-50SB-222200 50mg
A15230-5SB-222200 5mg
A15230-1SB-222200 1mg
A15230-100SB-222200 100mg
A15230-10SB-222200 10mg
A15230-10mM-DSB-222200 10mM * 1mL in DMSO
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