BMS-566419

• Description:

  BMS-566419 is an acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase (IMPDH) . Inosine monophosphate dehydrogenase (IMPDH) is a key enzyme in the de novo synthesis of guanosine nucleotides. BMS-566419 has clinical utility for the research of transplant rejection[1].

• UNSPSC:

  12352005

• Target:

  IMPDH

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/bms-566419.html

• Purity:

  99.68

• Solubility:

  DMSO : 12.5 mg/mL (ultrasonic)

• Smiles:

  O=C1C2=CC (F) =C (C (NC (C) (C3=CN=C (N4CCN (CC) CC4) C=C3) C) =O) C=C2NC5=CC=CC=C15

• Molecular Formula:

  C28H30FN5O2

• Molecular Weight:

  487.57

• References & Citations:

  [1]Watterson SH, et al. Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N- (2- (6- (4-ethylpiperazin-1-yl) pyridin-3-yl) propan-2-yl) -2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419) . J Med Chem. 2007;50 (15) :3730-3742.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  566161-24-8