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CJ-42794

CAT: 0804-HY-10797-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10797-01Size:5 mg
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Description
CJ-42794 (CJ-042794) is a potent, orally active, selective prostaglandin E receptor 4 (EP4) antagonist with an IC50 value of 10 nM, which is 200-fold more selective than EP1, EP2 and EP3. CJ-42794 can be used in research of gastric ulcers[1][2].
CAS Number
847728-01-2
Product Name Alternative
CJ-042794
UNSPSC
12352005
Hazard Statement
H317-H319
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/CJ-42794.html
Concentration
10mM
Purity
98.96
Solubility
DMSO : ≥ 28 mg/mL
Smiles
ClC1=CC=C(OC2=CC=C(F)C=C2)C(C(N[C@H](C3=CC=C(C(O)=O)C=C3)C)=O)=C1
Molecular Formula
C22H17ClFNO4
Molecular Weight
413.83
Precautions
P261-P264-P272-P280-P302+P352-P305+P351+P338-P362+P364-P501
References & Citations
[1]Murase A, et, al. In vitro pharmacological characterization of CJ-042794, a novel, potent, and selective prostaglandin EP (4) receptor antagonist. Life Sci. 2008 Jan 16;82 (3-4) :226-32.|[2]Takeuchi K, et, al. Effect of (S) -4- (1- (5-chloro-2- (4-fluorophenyoxy) benzamido) ethyl) benzoic acid (CJ-42794), a selective antagonist of prostaglandin E receptor subtype 4, on ulcerogenic and healing responses in rat gastrointestinal mucosa. J Pharmacol Exp Ther. 2007 Sep;322 (3) :903-12.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EP

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A21948-100CJ-42794 100mg
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A21948-5CJ-42794 5mg
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