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BCH

CAT: 0804-HY-108540-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-108540-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BCH (2-Amino-2-norbornanecarboxylic acid) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis[1][2][3].
CAS Number
20448-79-7
Product Name Alternative
2-Amino-2-norbornanecarboxylic acid; LAT1-IN-1
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bch.html
Concentration
10mM
Purity
99.13
Solubility
DMSO : < 1 mg/mL|H2O : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1(N)C(C2)CCC2C1)O
Molecular Formula
C8H13NO2
Molecular Weight
155.20
Precautions
H302, H315, H319, H335
References & Citations
[1]Ohshima Y, et al. Efficacy of system l amino acid transporter 1 inhibition as a therapeutic target in esophageal squamous cell carcinoma. Cancer Sci. 2016 Oct;107 (10) :1499-1505.|[2]Singh N, et al. Discovery of Potent Inhibitors for the Large Neutral Amino Acid Transporter 1 (LAT1) by Structure-Based Methods. Int J Mol Sci. 2018 Dec 21;20 (1) .|[3]Wang Q, et al. L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia. Am J Cancer Res. 2015 Mar 15;5 (4) :1281-94. eCollection 2015.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

2-Aminobicyclo(2,2,1)heptane-2-carboxylic acid

2-Amino-2-norbornanecarboxylic acid is a monoterpenoid.

CAS Number20448-79-7
PubChem CID115288
IUPAC Name2-aminobicyclo[2.2.1]heptane-2-carboxylic acid
Molecular FormulaC8H13NO2
Molecular Weight155.19
XLogP-1.9
Topological Polar Surface Area63.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Heavy Atom Count11
Formal Charge0
Complexity204
SMILES
C1CC2CC1CC2(C(=O)O)N
InChI
InChI=1S/C8H13NO2/c9-8(7(10)11)4-5-1-2-6(8)3-5/h5-6H,1-4,9H2,(H,10,11)
InChIKey
MPUVBVXDFRDIPT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-Aminobicyclo(2,2,1)heptane-2-carboxylic acid
CAS: 20448-79-7
CID: 115288
Formula: C8H13NO2
MW: 155.19
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight155.19
XLogP3-1.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass155.094628657
Monoisotopic Mass155.094628657
Topological Polar Surface Area63.3 Ų
Heavy Atom Count11
Formal Charge0
Complexity204
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count3
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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