BCH

• Description:

  BCH (2-Amino-2-norbornanecarboxylic acid) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis[1][2][3].

• Product Name Alternative:

  2-Amino-2-norbornanecarboxylic acid; LAT1-IN-1

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/bch.html

• Concentration:

  10mM

• Purity:

  99.13

• Solubility:

  DMSO : < 1 mg/mL|H2O : 20 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C(C1(N)C(C2)CCC2C1)O

• Molecular Formula:

  C8H13NO2

• Molecular Weight:

  155.20

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Ohshima Y, et al. Efficacy of system l amino acid transporter 1 inhibition as a therapeutic target in esophageal squamous cell carcinoma. Cancer Sci. 2016 Oct;107 (10) :1499-1505.|[2]Singh N, et al. Discovery of Potent Inhibitors for the Large Neutral Amino Acid Transporter 1 (LAT1) by Structure-Based Methods. Int J Mol Sci. 2018 Dec 21;20 (1) .|[3]Wang Q, et al. L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia. Am J Cancer Res. 2015 Mar 15;5 (4) :1281-94. eCollection 2015.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [20448-79-7]