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BCH

CAT: 0804-HY-108540-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108540-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BCH (2-Amino-2-norbornanecarboxylic acid) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis[1][2][3].
CAS Number
20448-79-7
Product Name Alternative
2-Amino-2-norbornanecarboxylic acid; LAT1-IN-1
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bch.html
Concentration
10mM
Purity
99.13
Solubility
DMSO : < 1 mg/mL|H2O : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1(N)C(C2)CCC2C1)O
Molecular Formula
C8H13NO2
Molecular Weight
155.20
Precautions
H302, H315, H319, H335
References & Citations
[1]Ohshima Y, et al. Efficacy of system l amino acid transporter 1 inhibition as a therapeutic target in esophageal squamous cell carcinoma. Cancer Sci. 2016 Oct;107 (10) :1499-1505.|[2]Singh N, et al. Discovery of Potent Inhibitors for the Large Neutral Amino Acid Transporter 1 (LAT1) by Structure-Based Methods. Int J Mol Sci. 2018 Dec 21;20 (1) .|[3]Wang Q, et al. L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia. Am J Cancer Res. 2015 Mar 15;5 (4) :1281-94. eCollection 2015.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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