SD-7300

CAT: 0804-HY-164525Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-164525Size:1 Each
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Description
SD-7300 (SC-81490) is an orally active inhibitor of MMP-2, MMP-9, and MMP-13 with Ki values of 0.03, 0.01, and 0.03 nM, respectively. SD-7300 can reduce the degradation of extracellular matrix by tumor cells, thereby inhibiting the invasion and metastasis of tumor cells. In addition, SD-7300 is also a dose-dependent inhibitor of mouse corneal angiogenesis and an inhibitor of interleukin-1-induced bovine cartilage degradation. SD-7300 can be used in breast cancer research[1].
CAS Number
[748120-89-0]
Product Name Alternative
SC-81490; PF-02881307
UNSPSC
12352005
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sd-7300.html
Smiles
O=C(C1(S(=O)(N2CCC(CC2)OC3=CC=C(C=C3)OC(F)(F)F)=O)CCN(CC1)CCOC)NO
Molecular Formula
C21H30F3N3O7S
Molecular Weight
525.54
References & Citations
[1]Winer, et al. "Inhibition of breast cancer metastasis by presurgical treatment with an oral matrix metalloproteinase inhibitor: a preclinical proof-of-principle study." Molecular cancer therapeutics 15.10 (2016) : 2370-2377.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-13; MMP-2; MMP-9

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