SD-7300

• Description :

  SD-7300 (SC-81490) is an orally active inhibitor of MMP-2, MMP-9, and MMP-13 with Ki values of 0.03, 0.01, and 0.03 nM, respectively. SD-7300 can reduce the degradation of extracellular matrix by tumor cells, thereby inhibiting the invasion and metastasis of tumor cells. In addition, SD-7300 is also a dose-dependent inhibitor of mouse corneal angiogenesis and an inhibitor of interleukin-1-induced bovine cartilage degradation. SD-7300 can be used in breast cancer research[1].

• Product Name Alternative :

  SC-81490; PF-02881307

• UNSPSC :

  12352005

• Target :

  MMP

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/sd-7300.html

• Smiles :

  O=C(C1(S(=O)(N2CCC(CC2)OC3=CC=C(C=C3)OC(F)(F)F)=O)CCN(CC1)CCOC)NO

• Molecular Formula :

  C21H30F3N3O7S

• Molecular Weight :

  525.54

• References & Citations :

  [1]Winer, et al. "Inhibition of breast cancer metastasis by presurgical treatment with an oral matrix metalloproteinase inhibitor: a preclinical proof-of-principle study." Molecular cancer therapeutics 15.10 (2016) : 2370-2377.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MMP-13; MMP-2; MMP-9

• CAS Number :

  [748120-89-0]