SD-6

• Description:

  SD-6 is an orally active inhibitor of hAChE and hBChE with IC50 values of 0.907 µM and 1.579 µM, respectively. SD-6 has excellent blood-brain barrier (BBB) permeability and no neurotoxicity, which can be used for research on Alzheimer's disease[1].

• UNSPSC:

  12352005

• Target:

  Cholinesterase (ChE)

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/sd-6.html

• Concentration:

  10mM

• Purity:

  98.0

• Solubility:

  10 mM in DMSO

• Smiles:

  S=C1OC(C2=CC=CC=C2)=NN1CN3CCN(CC3)CC4=CC=CC=C4

• Molecular Formula:

  C20H22N4OS

• Molecular Weight:

  366.48

• References & Citations:

  [1]Waiker DK, et al. Development and Evaluation of Some Molecular Hybrids of N- (1-Benzylpiperidin-4-yl) -2- ((5-phenyl-1,3,4-oxadiazol-2-yl) thio) as Multifunctional Agents to Combat Alzheimer's Disease. ACS Omega. 2023 Mar 2;8 (10) :9394-9414.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  AChE; BChE

• CAS Number:

  [744206-31-3]