SD-208

• UNSPSC Description:

  SD-208 is a selective?TGF-βRI (ALK5)?inhibitor with?IC50?of 48 nM, and > 100-fold selectivity over TGF-βRII.

• Target Antigen:

  TGF-β Receptor

• Type:

  Reference compound

• Related Pathways:

  TGF-beta/Smad

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/SD-208.html

• Purity:

  99.87

• Solubility:

  DMSO : 9.09 mg/mL (ultrasonic)

• Smiles:

  FC1=CC=C(Cl)C=C1C2=NC3=NC=CN=C3C(NC4=CC=NC=C4)=N2

• Molecular Weight:

  352.75

• References & Citations:

  [1]Uhl M, et al. SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo. Cancer Res. 2004 Nov 1;64(21):7954-61.|[2]Ge R, et al. Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-beta type I receptor kinase in vivo. Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4315-30.|[3]Sun Y, et al. Inhibition of intimal hyperplasia in murine aortic allografts by the oral administration of the transforming growth factor-beta receptor I kinase inhibitor SD-208. J Heart Lung Transplant. 2014 Jun;33(6):654-61.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  627536-09-8