SD-2301

• Description :

  SD-2301 is a selective STAT3 PROTAC degrader. SD-2301 induces STAT3 degradation without affecting the protein levels of other STAT family members (STAT1, STAT2, STAT4, STAT5, STAT6) . SD-2301 exerts anti-tumor effects in B16F10-bearing mice. SD-2301 can be used for the study of cancer. (Pink: STAT3 ligand (HY-172947), Blue: VHL Ligand (HY-172948), Black: Linker (HY-W577012), VHL ligand-linker conjugate (HY-172949) ) [1].

• UNSPSC :

  12352005

• Target :

  PROTACs; STAT

• Related Pathways :

  JAK/STAT Signaling; PROTAC; Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Smiles :

  O=C([C@@H](NC([C@@H]1CC[C@@H]2CCN(C[C@@H](C(N12)=O)NC(C3=CC4=C(N3)C=CC(C(P(O)(O)=O)=O)=C4)=O)C(CCCCC5=CN(N=N5)[C@@H](C(C)(C)C)C(N6C[C@@H](C[C@H]6C(N[C@H](C7=CC=C(C=C7)C8=C(N=CS8)C)C)=O)O)=O)=O)=O)CCC(N)=O)NCC(C=C9)=CC=C9S(=O)(CC)=O

• Molecular Formula :

  C64H80N13O15PS2

• Molecular Weight :

  1366.50

• References & Citations :

  [1]Zhou J, et al. STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity. Nature. 2025 May 14.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  STAT3; von Hippel-Lindau (VHL)

• CAS Number :

  [3054116-24-1]