SD 8381

• Description:

  SD 8381 is a potent and selective COX-2 inhibitor. SD 8381 shows IC50 values of 0.0098 μM for hCOX-2 and 0.69 μM for hCOX-1[1].

• UNSPSC:

  12352005

• Target:

  COX

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Inflammation/Immunology

• Smiles:

  ClC1=C2C (C=C ([C@H] (O2) C (F) (F) F) C (O) =O) =CC (Cl) =C1

• Molecular Formula:

  C11H5Cl2F3O3

• Molecular Weight:

  313.06

• References & Citations:

  [1]Wang JL, et al. The novel benzopyran class of selective cyclooxygenase-2 inhibitors-part I: the first clinical candidate. Bioorg Med Chem Lett. 2010 Dec 1;20 (23) :7155-8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  COX-2

• CAS Number:

  215123-80-1