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SD-7300

CAT: 0931-T200306-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T200306-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
748120-89-0
Target
MMP
Related Pathways
Proteases/Proteasome
Bioactivity
SD-7300 (SC-81490) functions as an orally active inhibitor targeting MMP-2, MMP-9, and MMP-13, exhibiting potent inhibition with K_i values of 0.03, 0.01, and 0.03 nM, respectively. By inhibiting these metalloproteinases, SD-7300 effectively reduces extracellular matrix degradation by tumor cells, thereby curbing their invasion and metastasis. Additionally, this compound acts as a dose-dependent inhibitor of mouse corneal angiogenesis and prevents interleukin-1-induced degradation of bovine cartilage. SD-7300 is applicable in the study of breast cancer.
Smiles
O=C(NO)C1(CCN(CCOC)CC1)S(=O)(=O)N2CCC(OC3=CC=C(OC(F)(F)F)C=C3)CC2
Molecular Formula
C21H30F3N3O7S
Molecular Weight
525.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

N-hydroxy-1-(2-methoxyethyl)-4-[4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl]sulfonylpiperidine-4-carboxamide
CAS Number748120-89-0
PubChem CID9893042
IUPAC NameN-hydroxy-1-(2-methoxyethyl)-4-[4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl]sulfonylpiperidine-4-carboxamide
Molecular FormulaC21H30F3N3O7S
Molecular Weight525.5
XLogP2
Topological Polar Surface Area126
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count12
Rotatable Bond Count9
Heavy Atom Count35
Formal Charge0
Complexity785
SMILES
COCCN1CCC(CC1)(C(=O)NO)S(=O)(=O)N2CCC(CC2)OC3=CC=C(C=C3)OC(F)(F)F
InChI
InChI=1S/C21H30F3N3O7S/c1-32-15-14-26-12-8-20(9-13-26,19(28)25-29)35(30,31)27-10-6-17(7-11-27)33-16-2-4-18(5-3-16)34-21(22,23)24/h2-5,17,29H,6-15H2,1H3,(H,25,28)
InChIKey
SMEDJCLQUBCAEY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-hydroxy-1-(2-methoxyethyl)-4-[4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl]sulfonylpiperidine-4-carboxamide
CAS: 748120-89-0
CID: 9893042
Formula: C21H30F3N3O7S
MW: 525.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight525.5
XLogP32
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count12
Rotatable Bond Count9
Exact Mass525.17565596
Monoisotopic Mass525.17565596
Topological Polar Surface Area126 Ų
Heavy Atom Count35
Formal Charge0
Complexity785
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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