SD-169

CAT: 0804-HY-W015445-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W015445-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SD-169 is an orally active ATP-competitive inhibitor of p38α MAPK, with an IC50 of 3.2 nM. SD-169 also weakly inhibits p38β MAPK with an IC50 of 122 nM. SD-169 prevents the development and progression of diabetes by inhibiting T cell infiltration and activation[1].
CAS Number
[1670-87-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
P38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/sd-169.html
Purity
99.44
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC2=C(NC=C2)C=C1)N
Molecular Formula
C9H8N2O
Molecular Weight
160.18
Precautions
H302, H315, H319, H335
References & Citations
[1]Medicherla S, et al. Preventive and therapeutic potential of p38 alpha-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes. J Pharmacol Exp Ther. 2006 Jul;318 (1) :99-107.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P38α; p38β

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