BMS-466442

• Description:

  BMS-466442 is a potent and selective inhibitor of asc-1 (alanine serine cysteine transporter-1), with an IC50 of 11 nM. BMS-466442 inhibits [3H] D-serine uptake into rat brain synaptosomes, with an IC50 of 400 nM. BMS-466442 can be used for schizophrenia research[1][2].

• UNSPSC:

  12352005

• Target:

  Adrenergic Receptor; ASCT; Dopamine Transporter

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/bms-466442.html

• Purity:

  98.99

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C ([C@H] (CC1=CN (C=N1) CC2=CC=CC=C2) NC (C3=CC4=C (C=C (C (OC) =C4) OCC5=CC=CC=C5) N3) =O) OC

• Molecular Formula:

  C31H30N4O5

• Molecular Weight:

  538.59

• References & Citations:

  [1]Brown JM, et al. In vitro Characterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10) . J Neurochem. 2014 Apr;129 (2) :275-83.|[2]Torrecillas IR, et al. Inhibition of the Alanine-Serine-Cysteine-1 Transporter by BMS-466442. ACS Chem Neurosci. 2019 May 15;10 (5) :2510-2517.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  α adrenergic receptor

• CAS Number:

  1598424-76-0