BMS-871

• Description :

  BMS-871 is an orally active pan-Notch inhibitor with IC50 values ​​of 4/1/4/3 nM for Notch1/2/3/4, respectively. BMS-871 significantly inhibited the proliferation of TALL-1 and MDA-MB-157 cells and demonstrated significant antitumor activity in T-acute lymphoblastic leukemia and triple-negative breast cancer xenograft models. BMS-871 can be used to study leukemia and breast cancer[1].

• UNSPSC :

  12352005

• Target :

  Notch

• Related Pathways :

  Neuronal Signaling; Stem Cell/Wnt

• Field of Research :

  Cancer

• Smiles :

  O=C(N[C@@H]1C(N(C)C2=CC=CC=C2C(C3=CC=CC=C3)=N1)=O)[C@H](CCC(F)(F)F)[C@H](C4=CC=CC=C4)C(N)=O

• Molecular Formula :

  C29H27F3N4O3

• Molecular Weight :

  536.54

• References & Citations :

  [1]Shan W, et al. BMS-871: a novel orally active pan-Notch inhibitor as an anticancer agent. Bioorg Med Chem Lett. 2015 May 1;25 (9) :1905-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1584631-89-9]