BMS-884775

• Description:

  BMS-884775 is a selective and orally active P2Y1 antagonist with an IC50 of 0.1 nM for the human P2Y1 receptor. BMS-884775 has a similar efficacy in preventing arterial thrombosis to Clopidogrel (HY-15283) and Prasugrel (HY-15284), but treatment with BMS-884775 results in shorter bleeding time and lower bleeding risk. BMS-884775 can be used in research related to antiplatelet and arterial thrombosis-associated diseases[1][2].

• UNSPSC:

  12352005

• Target:

  P2Y Receptor

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Cardiovascular Disease

• Smiles:

  O=C (NC1=NC2=CC=C (Cl) N=C2S1) NC3=CC=CC=C3N4CC5 (CCN (CC (C) (C) C) CC5) C6=C4C (O) =CC (F) =C6C7=CC=C (F) C=C7

• Molecular Formula:

  C36H35ClF2N6O2S

• Molecular Weight:

  689.22

• References & Citations:

  [1]Wong P, et al. Differential effects of P2Y1 versus P2Y12 receptor antagonism on thrombosis and bleeding in rabbits. European Heart Journal, 2013, 34 (suppl_1) : P1431.|[2]Tscharre M, et al. Novel Antiplatelet Agents in Cardiovascular Disease. J Cardiovasc Pharmacol Ther. 2020 May;25 (3) :191-200.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  P2Y1 Receptor

• CAS Number:

  1557206-59-3