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BMS-645737

CAT: 0804-HY-10335Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-10335Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BMS-645737 is an orally active, selective FGF receptor-1 and VEGF receptor-2 inhibitor. BMS-645737 selectively and competitively inhibits both VEGFR-2 and FGFR-1 tyrosine kinases. BMS-645737 has anti-angiogenic activity. BMS-645737 induces lesions in the incisor teeth[1].
CAS Number
[651744-16-0]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
FGFR; VEGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease; Inflammation/Immunology
Smiles
N=1N=C(OC1C2=CN3N=CN=C(NC=4C=NC=5NC(=CC5C4)C)C3=C2C(C)C)C
Molecular Formula
C20H20N8O
Molecular Weight
388.44
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Fletcher AM, et al. Incisor degeneration in rats induced by vascular endothelial growth factor/fibroblast growth factor receptor tyrosine kinase inhibition. Toxicol Pathol. 2010 Feb;38 (2) :267-79.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
FGFR1; VEGFR2/KDR/Flk-1

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