BMS-645737

• Description:

  BMS-645737 is an orally active, selective FGF receptor-1 and VEGF receptor-2 inhibitor. BMS-645737 selectively and competitively inhibits both VEGFR-2 and FGFR-1 tyrosine kinases. BMS-645737 has anti-angiogenic activity. BMS-645737 induces lesions in the incisor teeth[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  FGFR; VEGFR

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cardiovascular Disease; Inflammation/Immunology

• Smiles:

  N=1N=C(OC1C2=CN3N=CN=C(NC=4C=NC=5NC(=CC5C4)C)C3=C2C(C)C)C

• Molecular Formula:

  C20H20N8O

• Molecular Weight:

  388.44

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

• References & Citations:

  [1]Fletcher AM, et al. Incisor degeneration in rats induced by vascular endothelial growth factor/fibroblast growth factor receptor tyrosine kinase inhibition. Toxicol Pathol. 2010 Feb;38 (2) :267-79.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  FGFR1; VEGFR2/KDR/Flk-1

• CAS Number:

  [651744-16-0]