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RIPK1-IN-23

CAT: 0804-HY-157963Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-157963Size:1 Each
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Description
RIPK1-IN-23 (compound 19) is a RIPK1 inhibitor with potent anti-necroptotic effects in HT-29 cells (EC50 of 1.7 nM) . RIPK1-IN-23 shows anti-inflammatory activities[1].
CAS Number
3031534-16-1
UNSPSC
12352005
Target
Necroptosis; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ripk1-in-23.html
Solubility
10 mM in DMSO
Smiles
CN1C([C@H](COC2=CC=C(C=C21)C3=CC=C(C=C3)C#N)NC(C4=NNC(CC5=CC=CC=C5)=N4)=O)=O
Molecular Formula
C27H22N6O3
Molecular Weight
478.50
References & Citations
[1]YuFeng Xin, et al. Discovery of novel biaryl benzoxazepinones as dual-mode receptor-interacting protein kinase-1 (RIPK1) inhibitors. Bioorg Med Chem. 2024 Feb 15:100:117611.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK1

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