GNF-2-deg

• UNSPSC Description:

  GNF-2-deg is a PROTAC degrader for dengue virus envelope protein (DENV E protein) with DC50 of 0.83 μM. GNF-2-deg prevents viral entry by inhibiting E-mediated membrane fusion, prevents virion production by protein degradation, and thereby exhibits antiviral activity against DENV 2 with EC90 of 3.5 μM. GNF-2-deg exhibits antiviral activity against ZIKV, JEV, WNV and YFV with EC90 of 1.96-7.79 μM. (Pink: ligand for target protein (HY-161805); Black: linker (HY-42149); Blue: ligand for E3 ligase (HY-23095))[1]

• Target Antigen:

  Dengue virus; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/gnf-2-deg.html

• Smiles:

  O=C(NCCOCCOCCOC1=CC=C2C(C(N(C3CCC(NC3=O)=O)C2=O)=O)=C1)C4=CC=CC(C5=CC(NC6=CC=C(OC(F)(F)F)C=C6)=NC=N5)=C4

• Molecular Weight:

  762.69

• References & Citations:

  [1]Liu HY, et al., Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism. Nat Commun. 2024 Jun 19;15(1):5179.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported