Deg-1

• Description :

  Deg-1 is a a bifunctional probe with a cleavage group and a covalent binding group. Deg-1 covalently binds to the target nucleic acid, and serves as click-degrader to cleave a nucleic acid molecule. Deg-1 has potential to selectively cleave target nucleic acids in cells[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

• UNSPSC :

  12352005

• Target :

  Biochemical Assay Reagents

• Type :

  Reference compound

• Related Pathways :

  Others

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/deg-1.html

• Purity :

  99.45

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  [N-]=[N+]=NCCOCCOCCOCCOCCOCCN1C=NC=C1

• Molecular Formula :

  C15H27N5O5

• Molecular Weight :

  357.41

• References & Citations :

  [1]Bernardes G, et al. Method for targeted nucleic acid cleavage. World Intellectual Property Organization, WO2022034177 A1 2022-02-17.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2761446-55-1]