Deg-1

• UNSPSC Description:

  Deg-1 is a a bifunctional probe with a cleavage group and a covalent binding group. Deg-1 covalently binds to the target nucleic acid, and serves as click-degrader to cleave a nucleic acid molecule. Deg-1 has potential to selectively cleave target nucleic acids in cells[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

• Target Antigen:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/deg-1.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  [N-]=[N+]=NCCOCCOCCOCCOCCOCCN1C=NC=C1

• Molecular Weight:

  357.41

• References & Citations:

  [1]Bernardes G, et al. Method for targeted nucleic acid cleavage. World Intellectual Property Organization, WO2022034177 A1 2022-02-17.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2761446-55-1