DEG-77

• Description :

  DEG-77, is a IKZF2 and CK1α targeted molecular glue, with DC50s of 15.3 nM and 10 nM, respectively. DEG-77 possesses suitable pharmacokinetic properties, solubility, and selectivity for in vivo studies (t1/2=8h) . DEG-77 can be used for acute myeloid leukemia (AML) study[1].

• UNSPSC :

  12352005

• Target :

  Casein Kinase; Molecular Glues

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; PROTAC; Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/deg-77.html

• Concentration :

  10mM

• Purity :

  99.03

• Solubility :

  DMSO : 50 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles :

  O=C1C2=CC=C(C=C2CN1C3CCC(NC3=O)=O)NC(C4=CC5=C(OC4)C(OC)=CC=C5)=O

• Molecular Formula :

  C24H21N3O6

• Molecular Weight :

  447.44

• References & Citations :

  [1]David K Miyamoto, et al. Design and Development of IKZF2 and CK1α Dual Degraders. J Med Chem. 2023 Dec 28;66 (24) :16953-16979.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CK1

• CAS Number :

  [3032265-06-5]