DEG-77

• UNSPSC Description:

  DEG-77, a IKZF2 and CK1α targeted molecular glue, possesses suitable pharmacokinetic properties, solubility, and selectivity for in vivo studies (t1/2=8h)[1].

• Target Antigen:

  Casein Kinase; Molecular Glues

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;PROTAC;Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/deg-77.html

• Solubility:

  DMSO : 50 mg/mL (ultrasonic;warming;heat to 80°C)

• Smiles:

  O=C1C2=CC=C(C=C2CN1C3CCC(NC3=O)=O)NC(C4=CC5=C(OC4)C(OC)=CC=C5)=O

• Molecular Weight:

  447.44

• References & Citations:

  [1]David K Miyamoto, et al. Design and Development of IKZF2 and CK1α Dual Degraders. J Med Chem. 2023 Dec 28;66(24):16953-16979.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3032265-06-5