DEG-35

• Description:

  DEG-35 is a CRBN-dependent, dual IKZF2 and CK1α molecule glue degrader, with DC50 values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. DEG-35 activates the p53 apoptosis pathway. DEG-35 can be used in the research for Acute Myeloid Leukemia (AML) [1].

• UNSPSC:

  12352211

• Target:

  Casein Kinase; IKZF Family; Molecular Glues

• Related Pathways:

  Cell Cycle/DNA Damage; Immunology/Inflammation; PROTAC; Stem Cell/Wnt

• Field of Research:

  Cancer

• Purity:

  98.88

• Smiles:

  COC1=CC2=C(C=C(C=C2)C(NC3=CC4=C(C(N(C4)C5CCC(NC5=O)=O)=O)C=C3)=O)C=C1

• Molecular Formula:

  C25H21N3O5

• Molecular Weight:

  443.45

• References & Citations:

  [1]Sun-Mi Park, et al. Dual IKZF2 and CK1α degrader targets acute myeloid leukemia cells. Cancer Cell. 2023 Apr 10;41 (4) :726-739.e11.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2734910-37-1]