DEG-35

CAT: 0804-HY-172931-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-172931-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DEG-35 is a CRBN-dependent, dual IKZF2 and CK1α molecule glue degrader, with DC50 values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. DEG-35 activates the p53 apoptosis pathway. DEG-35 can be used in the research for Acute Myeloid Leukemia (AML) [1].
CAS Number
[2734910-37-1]
UNSPSC
12352211
Target
Casein Kinase; IKZF Family; Molecular Glues
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; PROTAC; Stem Cell/Wnt
Field of Research
Cancer
Purity
98.88
Smiles
COC1=CC2=C(C=C(C=C2)C(NC3=CC4=C(C(N(C4)C5CCC(NC5=O)=O)=O)C=C3)=O)C=C1
Molecular Formula
C25H21N3O5
Molecular Weight
443.45
References & Citations
[1]Sun-Mi Park, et al. Dual IKZF2 and CK1α degrader targets acute myeloid leukemia cells. Cancer Cell. 2023 Apr 10;41 (4) :726-739.e11.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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