GNF-2

• Description:

  GNF-2 is a highly selective, allosteric, non-ATP competitive inhibitor of Bcr-Abl. GNF-2 inhibits Ba/F3.p210 proliferation with an IC50 of 138 nM [1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  Bcr-Abl; SARS-CoV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/GNF-2.html

• Purity:

  99.82

• Solubility:

  DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C(C1=CC=CC(C2=CC(NC3=CC=C(OC(F)(F)F)C=C3)=NC=N2)=C1)N

• Molecular Formula:

  C18H13F3N4O2

• Molecular Weight:

  374.32

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Adrián FJ, et al. Allosteric inhibitors of Bcr-abl-dependent cell proliferation. Nat Chem Biol. 2006 Feb;2 (2) :95-102.|[2]Kim HJ, et al. The tyrosine kinase inhibitor GNF-2 suppresses osteoclast formation and activity. J Leukoc Biol. 2013 Oct 15.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Bcr-Abl

• CAS Number:

  [778270-11-4]